The objective of this manual is to provide best-practice guidance on university-government collaboration for climate change adaptation in LDCs. The manual addresses the key question on how university-government collaboration can be a source of knowledge generation and partnership for catalyzing climate-adaptation finance. The guidance manual aims to familiarize the reader with various concepts related to science-policy interface and collaboration for climate adaptation finance, identify areas where university-government collaborations can be established, and important enabling conditions, and steps for establishing and improving university-government coordination in support of access to climate finance for climate change adaptation.